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The large blood vessels are crucial for blood flow distribution in the body but they may be subjected to disease processes like atherosclerosis, and consequences thereof like aneurysm formation, stroke, and myocardial infarction.These diseases are associated to a majority of the mortality of cardiovascular disease, which may be as high as 33% of overall disease related mortality. The function of these blood vessels has successfully been studied in the framework of biology, physics, and imaging. While a decade ago vessel function was merely described in terms of average blood flow, overall compliance and distensibility, the turbulent development of computational resources and numerical modelling has enabled calculations of local wall stress, local blood flow, and local wall deformation.